Men, Women Process Pain Signals Differently

But to date, most of the research on pain has been done on male rodents.

The new study, led by researchers at The Ottawa Hospital in Canada, however, used female and male spinal cord tissue from both rats and humans (generously donated by deceased individuals and their families).

By examining spinal cord tissue in the laboratory, the researchers were able to show that a neuronal growth factor called BDNF plays a major role in increasing spinal pain in male humans and male mice, but not female humans or female mice. Not in.

When the ovaries of the female mice were removed, the difference disappeared, pointing to a hormonal connection.

“Development of new pain drugs requires a detailed understanding of how pain is processed at the biological level,” said study lead author Dr. Annemarie Dedek.

“This new discovery lays the foundation for the development of new therapies to help people with chronic pain.”

This is the first time that gender-related differences in pain signaling in human spinal cord tissue have been identified.

The researchers said future studies are needed to understand how this biological difference may contribute to differences in pain sensation between men and women.

Source: IANS

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