Genes That may Help Repair DNA in Cancer Identified


The team specifically identified two previously unknown proteins in the DNA repair process – SETD1A and BOD1L, which help to modify other DNA-bound proteins (called histones).

it was found that Removing these two proteins changes the way DNA is repaired, and makes cancer cells more sensitive to radiotherapy. In addition, loss of SETD1A and BOD1L renders cancer cells resistant to certain anti-cancer drugs called PARP inhibitors.

“This is the first time that these genes have been directly linked to DNA repair in cancer. This research has the potential to change how cancer patients are identified for treatment and also how they respond to different drugs.” How resistant are formed, which will improve treatment efficiency as well as patient outcomes,” says lead author Martin Higgs.

Source: MadeIndia



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