Aspirin may reduce death in hospitalized COVID-19 patients, study finds

Researchers at George Washington University published the findings of the world’s largest cohort study showing that hospitalized patients with moderate COVID-19 who were given aspirin early in their treatment had a lower risk of dying than patients who were not who were not given aspirin.

Lead researcher, Jonathan Chow, said, “This is our third study and the culmination of 15 months of work looking at the use of aspirin in hospitalized COVID-19 patients. We have found that aspirin use is associated with better outcomes and a lower rate of death in hospitalized patients. What’s more, it is low cost and readily available, which is important in parts of the world where more expensive medical science may not be accessible.

The study included the largest data set of 112,269 patients hospitalized with moderate COVID-19. The data included patients enrolled in 64 health systems in the United States, participating in the National Institutes of Health’s National COVID Cohort Collaborative (N3C), from January 1, 2020 to September 10, 2021.

Researchers found a 1.6% reduction in mortality when patients with moderate disease severity were given aspirin within the first day of hospitalization and patients were less likely to form blood clots. They also found that elderly patients and patients with one or more comorbidities particularly benefited from initial aspirin therapy.

Keith Crandall, director of the Computational Biology Institute (CBI) at George Washington University, the organization that helped collect and input GW’s data into the NIH database and curate the dataset in a format usable for statistical analysis, said, “This research is important to provide effective and accessible COVID-19 treatment to clinicians and patients in order to reduce hospital mortality and help people recover from this potentially devastating disease.”

Chow and his team have been focused on this topic since the beginning of the pandemic. Their first study was published in April 2021 and the second study was published in November 2021.

This latest study, “Early aspirin use with in-hospital mortality in patients with moderate COVID-19,” will be published March 24. jama network open,

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Material provided by George Washington University, Note: Content can be edited for style and length.

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